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Target intelligence / Profile preview
Neisseria meningitidis Serogroup Y Capsular Polysaccharide Antigen-Conjugated Protein Carrier (MenY CPS-Conjugate)
- Target
- MenY CPS-Conjugate
- Molecular classification
- Polysaccharide, Antigen, Conjugate Vaccine Component
01
Overview
The capsular polysaccharide antigen from *Neisseria meningitidis* serogroup Y, conjugated to a protein carrier (e.g., CRM197 or tetanus toxoid). This conjugate is a key component of vaccines designed to prevent invasive meningococcal disease caused by serogroup Y strains. The conjugation enhances immunogenicity, particularly in infants and young children, by converting the polysaccharide into a T-cell dependent antigen, leading to robust antibody production and immunological memory.
- Other names
- N. meningitidis serogroup Y polysaccharide conjugate vaccineMenY conjugate vaccineSerogroup Y capsular polysaccharide-protein conjugateY-CRM197Y-TT
02
Mechanism of action
Induces the production of antibodies that bind to the serogroup Y capsular polysaccharide, leading to complement-mediated killing and opsonophagocytosis of *Neisseria meningitidis* serogroup Y bacteria.
03
Biological functions
Antigen presentationInduction of humoral immunityOpsonizationComplement activationBacterial neutralization
04
Disease associations
InfectionMeningococcal diseaseBacterial meningitisSepsis
05
Safety considerations
Injection site reactionsFeverHypersensitivity reactions (rare)Guillain-Barré syndrome (very rare)
06
Interacting drugs
MenACWY conjugate vaccines
1 more in the full profile.
07
Biomarkers
Anti-capsular polysaccharide antibody titers (IgG)Serum bactericidal antibody (SBA) titers
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