Target intelligence / Profile preview

Neisserial adhesin A (None)

Target: None
Molecular classification: Trimeric autotransporter adhesin (TAA), Oligomeric coiled-coil adhesin, Surface adhesion protein

Overview

Neisserial adhesin A (NadA) is a trimeric autotransporter protein found on the surface of certain strains of *Neisseria meningitidis*. NadA plays a critical role in mediating adhesion to and invasion of host tissues, contributing to the bacterium's virulence. It is also an important immunogen and a key antigen included in the licensed anti-meningococcus B vaccine 4CMenB.

Mechanism of action

Induction of neutralizing antibodies

Biological functions

Adhesion to host cellsInvasion of host tissuesImmune modulationReceptor binding

Disease associations

InfectionMeningitisSepticemia

Interacting drugs

4CMenB (component)

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