Nematode GABA-gated chloride channel (None commonly used; sometimes abbreviated as GABA_A receptor (rare in nematode literature)[5])

The Nematode GABA-gated chloride channel is a pentameric, ligand-gated ion channel receptor that mediates inhibitory neurotransmission at nematode neuromuscular junctions by allowing chloride ions to enter the cell in response to GABA binding; this hyperpolarizes the membrane, inhibiting muscle contraction and critical physiological behaviors such as locomotion and feeding[1][5]. These channels belong to the cys-loop receptor superfamily, are composed of multiple subunit genes with species-specific diversity, and are important molecular targets for the macrocyclic lactone class of anthelmintic drugs, including ivermectin. Mutations in these channels can cause drug resistance, complicating parasite control and prompting the search for resistance biomarkers[2].

Other names

GABA receptorGABA_A receptor (context-dependent, but less common in nematode studies)[5]GABA-gated ion channelLigand-gated chloride channel (GABA subtype)[2]

Positive allosteric modulation by drugs like ivermectin causes prolonged channel opening, leading to hyperpolarization and inhibition of neuromuscular transmission in nematodes, resulting in paralysis and death[4][2]. Agonism by GABA and drug ligands leads to increased chloride flux, inhibiting cell activity and muscle contraction[5][1].