Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Nematode-specific nicotinic acetylcholine receptor subunit Hco-MPTL-1 (Hco-MPTL-1)
- Target
- Hco-MPTL-1
- Molecular classification
- Ligand-gated ion channel, Receptor, Nicotinic acetylcholine receptor (nAChR), DEG-3 nAChR subfamily
01
Overview
Hco-MPTL-1 is a nematode-specific subunit of nicotinic acetylcholine receptors (nAChRs), primarily found in the parasitic nematode Haemonchus contortus. It belongs to the DEG-3 subfamily of nAChRs, which are ligand-gated ion channels involved in excitatory neurotransmission. This receptor is a primary molecular target of the anthelmintic drug monepantel. Mutations in hco-mptl-1 are associated with resistance to monepantel.
- Other names
- hc-acr-23H
02
Mechanism of action
Selective targeting of Hco-MPTL-1, leading to paralysis and death of susceptible worms
03
Biological functions
Cholinergic neurotransmissionExcitatory neurotransmission
04
Disease associations
Parasitic worm infection
05
Safety considerations
Development of drug resistance due to mutations in hco-mptl-1
06
Interacting drugs
Monepantel
2 more in the full profile.
Beyond the preview
Go deeper on Nematode-specific nicotinic acetylcholine receptor subunit Hco-MPTL-1 (Hco-MPTL-1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Nematode-specific nicotinic acetylcholine receptor subunit Hco-MPTL-1 (Hco-MPTL-1).