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Target intelligence / Profile preview
Tumor-specific Neoantigen Peptide-HLA Complex (pHLA)
- Target
- pHLA
- Molecular classification
- Complex, Peptide-MHC Complex, Antigen presentation complex
01
Overview
Tumor-specific neoantigen peptide-HLA complexes are formed when mutated peptides derived from tumor cells are presented on the cell surface by human leukocyte antigen (HLA) molecules. These complexes serve as targets for T cell recognition and cancer immunotherapy. They play a crucial role in signaling the presence of cancerous cells to the immune system, leading to T cell activation and tumor rejection. Targeting these complexes is a promising avenue for personalized cancer immunotherapy.
- Other names
- Neoantigen-HLA ComplexTumor-specific antigen presentationMutated peptide-HLA complex
02
Mechanism of action
Presentation of tumor-specific mutated peptides to T cells, leading to T cell activation and tumor cell lysis.
03
Biological functions
Antigen presentationT cell activationImmune recognitionTumor rejectionAdaptive immunity
04
Disease associations
CancerImmune evasionTarget for immunotherapy
05
Safety considerations
Off-target effectsAutoimmunityCytokine release syndromeTumor heterogeneityLow expression levels
06
Interacting drugs
Neoantigen vaccines
3 more in the full profile.
07
Biomarkers
Neoantigen expressionHLA typeT cell infiltrationTCR repertoireMutational burden
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