Neoantigen-presenting cell

Neoantigen-presenting cell refers to professional antigen-presenting cells (APCs)—such as dendritic cells, macrophages, or B cells—that acquire, process, and display tumor-specific mutated peptides (neoantigens) in complex with MHC molecules to T cells. This function is crucial for initiating adaptive immune responses against tumors, particularly in the context of cancer vaccine approaches and immunotherapies. These cells are not a single drug target but rather a critical functional component of the tumor-immune microenvironment, responsible for priming T cells against neoantigen-expressing cancer cells[1][2][4][6].

Other names

Antigen-presenting cellAPCdendritic cell (when context specifies DC as the major presenter)professional antigen-presenting cell