Neovascular endothelium

"Neovascular endothelium" refers to the endothelial cells lining newly formed blood vessels that arise during pathological angiogenesis, such as in choroidal neovascularization seen in age-related macular degeneration and certain cancers. These cells are characterized by increased proliferation and altered molecular profiles compared to normal vascular endothelium. In therapies like photodynamic therapy for AMD, drugs such as verteporfin are selectively taken up by these proliferative endothelial cells due to their high expression of low-density lipoprotein receptors. Upon photoactivation, verteporfin generates reactive oxygen species that induce oxidative damage, leading to targeted destruction of the neovasculature[1]. However, "neovascular endothelium via photoactivation-induced oxidative damage" is not a canonical molecular target or receptor; rather, it describes a therapeutic strategy targeting a cell population through induced oxidative stress. Note: This entry is problematic as a drug target because it does not refer to a specific molecule or receptor but rather an entire cell type affected by a treatment mechanism. The actual molecular targets involved may include cellular components susceptible to oxidative stress or specific surface proteins mediating drug uptake[1].

Other names

Neovascular endothelial cellPathological endothelium (in context of neovascularization)

Photoactivation-induced oxidative damage to proliferating endothelial cells