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Target intelligence / Profile preview
Neovascularization associated with tendinopathy
- Molecular classification
- Other
01
Overview
Neovascularization associated with tendinopathy involves the aberrant growth of small blood vessels and accompanying nerves into normally hypovascular tendon tissue. This process is driven by factors such as increased expression of VEGF and matrix metalloproteinases (MMPs), contributing to extracellular matrix degradation, chronic pain, and further tendon degeneration. While neovessel detection by Doppler ultrasound is diagnostic, therapeutic targeting of neovessels or their drivers is experimental and carries potential risks.
- Other names
- Neovessel ingrowth in tendinopathyAngiogenesis in tendinopathyTendon neovascularization
02
Mechanism of action
Inhibition of angiogenesis (anti-VEGF); Vessel sclerosis/obliteration (sclerosing injections); Anti-inflammatory effects (corticosteroids)
03
Biological functions
Angiogenesis (formation of new blood vessels)Nerve ingrowthMatrix remodelingTissue degeneration
04
Disease associations
Chronic tendinopathyPain syndromesTissue degeneration
05
Safety considerations
Possible tissue necrosis or impaired healing (with anti-angiogenic or sclerosing therapy)Increased risk of tendon rupture (with corticosteroid use)
06
Interacting drugs
Sclerosing agents (for example, polidocanol)
2 more in the full profile.
07
Biomarkers
Vascular endothelial growth factor (VEGF)Doppler ultrasound detection of neovessels
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