Nephronectin (NPNT)

Nephronectin (NPNT) is a secreted extracellular matrix protein characterized by five N-terminal EGF-like repeats, a proline-rich central region with integrin-binding RGD and LFEIFEIER motifs, and a C-terminal MAM domain[1][2][4]. It functions primarily as a high-affinity ligand for integrin α8β1, playing a pivotal role in basement membrane assembly and organogenesis, particularly in kidney and heart development[1][2][4]. NPNT supports tissue morphogenesis by modulating signaling pathways (e.g., PI3K-AKT via EGFR, ERK1/2, p38 MAPK), guiding cell adhesion and differentiation, and promoting angiogenesis in both physiological and pathological contexts such as bone formation and cancer[1][2][3][4]. Its altered expression or dysfunction is implicated in developmental disorders (e.g., renal agenesis, Fraser syndrome) and cancer metastasis, while serving as a marker of tissue differentiation and potential biomarker in disease states[2][3][4]. No approved drugs directly target NPNT, and it is not currently established as a direct therapeutic target[1][2][4].

Other names

POEMEGFL6LPreosteoblast EGF-like repeat protein with MAM domainProtein EGFL6-likeUNQ295/PRO334