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Target intelligence / Profile preview
Nerve Growth Factor (NGF)
- Target
- NGF
- Molecular classification
- Neurotrophin, Neuropeptide
01
Overview
Nerve Growth Factor (NGF) is a well-characterized neurotrophic factor and neuropeptide, primarily known for its critical role in the growth, maintenance, proliferation, and survival of certain neurons. It is essential for the development and survival of sympathetic and sensory neurons and has roles beyond neural development, including immune function, stress response, and wound healing. Dysregulation is implicated in chronic pain.
02
Mechanism of action
NGF exerts its effects by binding to two main types of cell surface receptors: TrkA (NTRK1) and p75 Neurotrophin Receptor (p75NTR). The binding to TrkA promotes neuron growth and blocks apoptosis. Binding to p75NTR can lead to either cell survival or programmed cell death depending on co-receptor interactions.
03
Biological functions
Neuronal growthNeuronal differentiationNeuronal maintenanceNeuronal proliferationApoptosis regulationImmune functionStress responseWound healing
04
Disease associations
Chronic pain conditionsGlaucomaMaculopathyRetinitis pigmentosa
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