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Target intelligence / Profile preview
Nerve Growth Factor Receptor p75NTR (p75NTR)
- Target
- p75NTR
- Molecular classification
- Type I transmembrane glycoprotein, Tumor necrosis factor receptor superfamily, Receptor
01
Overview
p75NTR is a type I transmembrane glycoprotein receptor belonging to the tumor necrosis factor receptor (TNFR) superfamily. It acts as a pan-neurotrophin receptor, binding all neurotrophins and their proforms. p75NTR plays crucial roles in regulating cell death and survival, neuronal development, tissue remodeling, energy expenditure, hypoxic response, scar formation, and neurodegeneration. It's a key regulator of cell fate, influencing survival, apoptosis, neurite outgrowth and synaptic plasticity. The outcome of p75NTR activation depends on the specific ligand bound (mature vs. proneurotrophins), presence of co-receptors such as TrkA/B/C or sortilin, and the cellular context. Therapeutic targeting of p75NTR is under investigation for neurological disorders.
- Other names
- Low-affinity nerve growth factor receptorNGFRCD271
02
Mechanism of action
Modulation of pro-survival/pro-apoptotic functions via peptides/small molecules.
03
Biological functions
Cell fate determination - survival vs apoptosisNeurite outgrowthSynaptic plasticityAxonal growth regulationScar formationEnergy metabolism regulationHypoxic responses
04
Disease associations
Neurodegenerative diseaseAlzheimer's diseaseAmyotrophic lateral sclerosis (ALS)Psychiatric disordersCancer
05
Safety considerations
Potential for unintended consequences due to complex signaling pathways (NF-kB, RhoA, JNK)Off-target effects due to broad ligand binding (all neurotrophins and proneurotrophins)
06
Biomarkers
p75NTR expression levels (e.g., in ALS)
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