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Target intelligence / Profile preview
Nerve Growth Factor Receptor TrkA (TrkA)
- Target
- TrkA
- Molecular classification
- Receptor tyrosine kinase (RTK), Receptor
01
Overview
Nerve Growth Factor Receptor TrkA is a receptor tyrosine kinase that binds NGF with high affinity and mediates most of NGF's biological effects, including neuronal survival, differentiation, and pain perception. It is involved in various diseases, including congenital insensitivity to pain, intellectual disability, and certain cancers, making it a target for therapeutic intervention.
- Other names
- Tropomyosin receptor kinase Ahigh affinity nerve growth factor receptorneurotrophic tyrosine kinase receptor type 1TRK1-transforming tyrosine kinase protein
02
Mechanism of action
NGF binding induces receptor dimerization and autophosphorylation, activating downstream signaling pathways (Ras/MAPK, PI3K/Akt, PLCγ) that regulate neuronal survival, differentiation, and other functions.
03
Biological functions
Signal transductionNeuronal differentiationNeuron survivalCell proliferationNociceptionInhibition of apoptosis
04
Disease associations
Congenital insensitivity to pain with anhidrosis (CIPA)Intellectual disability/cognitive impairmentNeuroblastomaPapillary thyroid carcinomaCancerPain
05
Safety considerations
Potential for off-target effects when developing TrkA inhibitors for pain management.Development of resistance to targeted therapies in cancer due to mutations in NTRK1 or bypass mechanisms.
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