Nervous system modulation via relaxation response induction (null)

The relaxation response is a physiological state opposite to the fight-or-flight stress response, characterized by activation of the parasympathetic nervous system ("rest and digest") and changes in gene expression that counteract stress at both the molecular and systemic levels. It is elicited by practices such as meditation, deep breathing, yoga, and prayer, and is associated with reduced heart rate, lower blood pressure, decreased oxygen consumption, increased nitric oxide production, and improved sense of well-being. Long-term induction promotes favorable changes in gene expression related to inflammation, cellular metabolism, and longevity, and can help prevent or ameliorate stress-related disorders such as hypertension, anxiety, and insomnia. While not a classic drug target, the relaxation response is a well-documented mechanism for nervous system modulation, health maintenance, and disease prevention. For further structured mapping, select specific molecular targets involved in the parasympathetic nervous system or stress modulation, such as "Muscarinic acetylcholine receptor M2," "Nitric oxide synthase," or "Corticotropin-releasing hormone receptor," rather than procedural or descriptive terms.

Other names

Relaxation responseRRParasympathetic nervous system activationRest and digest response

Activation of the parasympathetic nervous system via acetylcholine signaling; Increased nitric oxide production for vasodilation; Reduction in stress hormone secretion (cortisol, catecholamines); Modulation of gene expression in stress and inflammatory pathways; Enhancement of mitochondrial function and energy metabolism