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Target intelligence / Profile preview
Netrin-1 (NTN1)
- Target
- NTN1
- Molecular classification
- Laminin-related secreted protein
01
Overview
Netrin-1 is a multifunctional secreted protein essential for guiding developing neurons/axons across CNS midlines but also plays major roles outside the nervous system—including angiogenesis organ morphogenesis inflammation regulation—with diverse effects mediated through specific membrane-bound receptors such as DCC UNC5 neogenin DSCAM.
- Other names
- NTN1 ligandNetrin 1
02
Mechanism of action
Attraction/repulsion of cells via receptor binding
03
Biological functions
Axon guidanceCell migrationAngiogenesisCell adhesionCytoskeletal reorganizationMorphogenesisInflammation regulation
04
Disease associations
CancerCardiovascular diseaseNeurodegenerative diseaseCongenital movement disorders
05
Safety considerations
Dual role as attractant and repellant depending on receptor contextPotential for tumorigenesis through altered cell migration/invasion
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