Netrin-1 receptor DCC (DCC)

Netrin-1 receptor DCC (deleted in colorectal carcinoma) is a single-pass transmembrane receptor in the immunoglobulin superfamily, primarily known for its critical role in axon guidance in the developing nervous system[2][3][1]. DCC binds the secreted ligand netrin-1, forming a complex that can trigger either attraction or repulsion in migrating neurons, depending on the combination of co-receptors present[1][4]. DCC is a “dependence receptor”: when occupied by netrin-1, it promotes neural development, axonal pathfinding, and cell migration; in the absence of ligand, DCC triggers apoptosis, acting as a tumor suppressor to inhibit abnormal cell proliferation[2][3]. Loss or mutation of DCC is associated with the development and progression of colorectal cancer and may serve as a diagnostic biomarker and potential therapeutic target, though there are currently no drugs on the market that directly target DCC[2][3]. The receptor contains multiple extracellular immunoglobulin-like and fibronectin type III domains, a single transmembrane region, and intracellular motifs for downstream signaling protein recruitment and caspase-mediated cleavage[3][1]. Because of its dual signaling roles (survival/proliferation versus apoptosis depending on ligand binding), DCC is tightly regulated and implicated in both healthy neural development and tumor suppression[2][3][1].

Other names

Netrin receptor DCCIGDCC1NTN1R1Colorectal cancer suppressorTumor suppressor protein DCCImmunoglobulin superfamily DCC subclass member 1CRC18CRCR1HGPPS2MRMV1Deleted in colorectal carcinoma

Not applicable (no approved drugs targeting DCC directly). Hypothetical mechanisms include blocking DCC-netrin-1 binding, mimicking netrin-1 to alter receptor activity, or modulating downstream pathway signaling.