Netrin receptor UNC5A (UNC5A)

Netrin receptor UNC5A is a transmembrane receptor of the immunoglobulin superfamily that binds netrin-1 and mediates repulsive axon guidance signals during neural development[2][3][4][5]. UNC5A serves crucial roles in directing neural growth cone migration and in promoting neurite outgrowth in response to netrin-1, often working together with other netrin receptors such as DCC. Uniquely, UNC5A functions as a "dependence receptor," inducing apoptosis in the absence of netrin-1 ligand, which is thought to contribute to its role as a candidate tumor suppressor[3][5]. In addition to neural patterning, UNC5A is implicated in regulating cell migration and proliferation across multiple tissues, with aberrations or loss of function associated with impaired cell guidance and certain cancers[1][3][4][5]. If you need more information on specific aspects such as structure, binding sites, or signaling partners, please specify.

Other names

UNC5AKIAA1976UNC5H1Protein unc-5 homolog 1Protein unc-5 homolog Anetrin receptor UNC5Anetrin receptor Unc5h1unc-5 homolog 1unc-5 homolog Aprotein unc-5 homolog 1protein unc-5 homolog Aunc-5 (C. elegans homolog) a

Modulators of netrin-1 or interference with UNC5A ligand binding would affect axon guidance and apoptosis. Small molecules or antibodies that block/activate netrin-1–UNC5A interaction may modulate cell survival and migration (theoretical and preclinical stage)