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NeuGc-containing Gangliosides (NeuGc-gangliosides)
- Target
- NeuGc-gangliosides
- Molecular classification
- Glycosphingolipid, Ganglioside, Tumor-associated antigen
01
Overview
NeuGc-containing gangliosides are a class of glycosphingolipids characterized by the presence of N-glycolylneuraminic acid (NeuGc) as their terminal sialic acid. These molecules are structurally similar to the more common N-acetylneuraminic acid (NeuAc)-containing gangliosides but differ by a single oxygen atom. In humans, NeuGc is not synthesized endogenously but can be incorporated into tissues from dietary sources, and are found selectively on tumor cells, making them tumor-associated antigens and targets for immunotherapy.
- Other names
- N-glycolylneuraminic acid-containing gangliosidesGM3(NeuGc)Tumor-associated NeuGc-gangliosidesNeu5Gc-containing gangliosides
02
Mechanism of action
Antibody-dependent cell-mediated cytotoxicity (ADCC), Induction of anti-tumor immune response
03
Biological functions
Cell-cell communicationSignal transductionImmune evasionAltered signaling pathways
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects in tissues with low levels of NeuGc expression due to dietary incorporation.Induction of autoimmunity.
06
Interacting drugs
chP3
4 more in the full profile.
07
Biomarkers
Expression levels of NeuGc-containing gangliosides in tumor tissue
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