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Target intelligence / Profile preview
Neural cell adhesion molecule 1 (NCAM1)
- Target
- NCAM1
- Molecular classification
- Immunoglobulin superfamily, Glycoprotein
01
Overview
Neural cell adhesion molecule 1 (NCAM1), also known as CD56, is a multifunctional glycoprotein belonging to the immunoglobulin superfamily. It plays critical roles in cell adhesion, migration, signaling, and development across neural and immune systems. It exists as several isoforms (NCAM-180, NCAM-140, NCAM-120) and is widely expressed in neurons, glial cells, skeletal muscle, NK cells, T lymphocytes, B lymphocytes, and dendritic cells. Alterations in NCAM/CD56 expression or signaling have been linked to cognitive deficits such as schizophrenia or Alzheimer's disease, and hereditary motor sensory neuropathy (CMT).
- Other names
- CD56MSK39NCAM[2]
02
Biological functions
Cell adhesionCell migrationSignal transductionNeurodevelopmentSynaptic plasticityRegulation of neurogenesisNeurite outgrowthAxonal guidanceSynapse formation/stabilizationLearningMemoryImmune regulationRegulation of expansion/migration of NK/T/B lymphocytes
03
Disease associations
SchizophreniaAlzheimer's diseaseHereditary motor sensory neuropathy (CMT)
04
Biomarkers
NK cell markerT cell subset marker
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