Neural precursor cell–expressed developmentally downregulated protein 8 activating enzyme (NAE)

The NEDD8-activating enzyme (NAE) is a crucial E1 enzyme in the neddylation pathway, responsible for activating the ubiquitin-like protein NEDD8. This activation is essential for the post-translational modification of target proteins, primarily cullin family members, which are key components of cullin-RING ubiquitin ligases (CRLs). The neddylation process regulates protein degradation and turnover, impacting cell cycle progression, DNA damage response, stress signaling, and other vital cellular processes. Aberrant neddylation contributes to tumorigenesis and viral replication, making NAE a valid therapeutic target.

Other names

NEDD8-activating enzymeAPPBP1/UBA3 complex

Inhibition of NEDD8 activation, leading to disruption of CRL-mediated proteolysis and downstream effects on cell cycle, DNA replication, and apoptosis.