Neural precursor cell expressed developmentally down-regulated protein 1 (NEDD1)

Neural precursor cell expressed developmentally down-regulated protein 1 (NEDD1) is a highly conserved centrosomal protein critical for the recruitment and anchoring of the γ-tubulin ring complex (γ-TuRC) to microtubule-organizing centers such as the centrosome and mitotic spindle poles[1][3][4][5]. NEDD1 contains an N-terminal WD40 domain, which mediates centrosomal and microtubule anchoring, and a C-terminal domain, which interacts directly with γ-TuRC[1][6]. NEDD1 ensures efficient microtubule nucleation and the assembly of a functional bipolar spindle during mitosis[2][4]. Its function is tightly regulated by phosphorylation, particularly during mitosis, which modulates its binding to γ-tubulin and recruitment capabilities[2]. Depletion or functional disruption of NEDD1 results in abnormal spindle formation, failed microtubule nucleation at centrosomes, and defective chromosome segregation, highlighting its essential role in cell cycle progression[2][4][5]. While there is growing interest in its dysfunction in cancer and possible neurodevelopmental roles, NEDD1 is not currently considered a direct therapeutic target and no drugs are known to interact with it or modulate its function[4].

Other names

NEDD1NEDD-1GCP-WDTUBGCP7Protein NEDD1Neural precursor cell expressed, developmentally down-regulated protein 1tubulin gamma complex associated protein 7