Neural tube formation pathways

Neural tube formation pathways refer to the ensemble of molecular signaling mechanisms and cellular processes that govern neurulation, the embryonic development event converting the neural plate into the neural tube, which later gives rise to the brain and spinal cord[1][3][4][5][7]. This involves coordinated actions of numerous pathways—including Wnt (canonical and non-canonical/planar cell polarity), Sonic hedgehog (Shh), bone morphogenetic protein (BMP), fibroblast growth factor (FGF), retinoic acid, Notch signaling, receptor tyrosine kinase-like orphan receptor (ROR), and others—which regulate processes such as cell proliferation, migration, polarity, shape changes (apical constriction), and patterning of neuroepithelial cells[4][7]. Improper regulation results in neural tube defects, which are significant causes of morbidity and mortality worldwide[3][4]. While components of these pathways can be considered drug targets, the term "neural tube formation pathways" is not itself a molecular target, but rather a developmental process composed of many interacting molecular modules.

Other names

Neural tube formationneurulation pathwaysneural tube morphogenesis signaling