Neuralized E3 ubiquitin protein ligase 1B (NEURL1B)

Neuralized E3 ubiquitin protein ligase 1B (NEURL1B) is an enzyme in the neuralized family of E3 ubiquitin ligases, playing a regulatory role in the ubiquitin-proteasome pathway by mediating the ubiquitination of specific substrate proteins such as Notch ligands. It is involved in the modulation of Notch signaling, influencing cellular differentiation, particularly during neurodevelopment. NEURL1B is localized to the actin cytoskeleton and cytosol. It is predicted to contribute to ubiquitin-dependent endocytosis but distinct from related enzymes (e.g., NEURL1), may have unique or only partially overlapping substrates and roles. Genetic associations suggest potential roles in congenital and developmental disorders, with limited direct disease linkages known to date[3][5][6].

Other names

NEUR2NEURL3DKFZP761M1511RNF67BhNeur2Neuralized-2Neuralized-like protein 1BNeuralized-like protein 3RING-type E3 ubiquitin transferase NEURL1BNeuralized homolog 1BE3 ubiquitin-protein ligase NEURL3neuralized 2 alternative protein

Ubiquitin ligase activity, facilitates the ubiquitination and subsequent proteasomal degradation or trafficking of substrate proteins, especially Notch ligands[5].