Neuralized E3 ubiquitin protein ligase 4 (NEURL4)

Neuralized E3 ubiquitin protein ligase 4 (NEURL4) is a centriolar protein belonging to the Neuralized family, characterized by E3 ubiquitin ligase activity. It primarily localizes to the daughter centriole and interacts with CP110, promoting its ubiquitination and subsequent proteasomal degradation. This post-translational modification of CP110 by NEURL4 is essential for the maintenance of centriolar homeostasis and prevention of ectopic microtubule-organizing centers, thereby ensuring normal cell division and centrosome function. Loss or depletion of NEURL4 leads to accumulation of CP110, formation of aberrant centrosome structures, and mitotic defects, which are processes relevant to cellular genomic stability but not directly targeted by current therapeutics[1][2][7].

Other names

Neuralized-like protein 4NEURL4KIAA1787neuralized homolog 4neuralized-like protein 4

Modulation of NEURL4 would theoretically alter CP110 ubiquitination and centriolar homeostasis, but no approved drugs or clinical interventions are known