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Target intelligence / Profile preview
Influenza A Virus Neuraminidase (NA)
- Target
- NA
- Molecular classification
- Enzyme, Glycoprotein, Viral Protein
01
Overview
Influenza A virus neuraminidase (NA) is a surface glycoprotein enzyme critical for the viral life cycle. It is essential for efficient viral replication, spread, and pathogenesis. NA acts as an exosialidase, cleaving α-ketosidic linkages between sialic acid and adjacent sugar residues, facilitating release of progeny viruses from infected cells and preventing self-aggregation. Neuraminidase inhibitors are key antiviral drugs that target NA's enzymatic activity, blocking viral release.
- Other names
- NeuraminidaseSialidase
02
Mechanism of action
Competitive inhibition of neuraminidase enzymatic activity, blocking viral release from infected cells.
03
Biological functions
Viral releaseSialic acid cleavageVirus motilityInfection spread
04
Disease associations
InfectionInfluenza
05
Safety considerations
Development of drug resistance due to mutations.Potential for reduced drug binding efficacy.Antigenic drift altering epitopes.
06
Interacting drugs
Zanamivir
3 more in the full profile.
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