Target intelligence / Profile preview

Neuraminidase A (NanA)

Target: NanA
Molecular classification: Enzyme, Sialidase, Neuraminidase, Cell wall-bound protein

Overview

Neuraminidase A (NanA) is a sialidase enzyme produced by the bacterium Streptococcus pneumoniae. It plays a crucial role in bacterial colonization, pathogenesis, and host interaction by cleaving terminal sialic acids from host glycoconjugates. NanA promotes pneumococcal adherence to human respiratory epithelial cells and biofilm formation. Its enzymatic activity exposes underlying receptors on host tissues that facilitate further bacterial attachment and invasion. NanA upregulates pro-inflammatory cytokines (IL1β, IL8, TNF) and modulates immune responses during infection.

Mechanism of action

Inhibition of sialic acid cleavage

Biological functions

Sialic acid cleavageBiofilm formationEpithelial adherenceImmune modulationBacterial colonization

Disease associations

InfectionStreptococcus pneumoniae infectionPneumonia

Interacting drugs

DANA (N-acetyl-2,3-dehydro-2-deoxyneuraminic acid)

Beyond the preview

Go deeper on Neuraminidase A (NanA).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Neuraminidase A (NanA).

Explore the full profile