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Target intelligence / Profile preview
Neuraminidase protein (NA)
- Target
- NA
- Molecular classification
- Enzyme, Glycoprotein
01
Overview
Neuraminidase (NA) is a major surface glycoprotein found on influenza A viruses, including the H5N1 subtype. It functions as a sialidase, cleaving terminal sialic acid residues to facilitate the release of progeny virions from infected host cells. NA is essential for efficient viral spread and is a key target for antiviral drugs like oseltamivir and zanamivir. However, mutations in the NA gene can lead to drug resistance and antigenic drift, posing challenges for treatment and vaccine development.
- Other names
- SialidaseNeuraminidase (NA) protein of Influenza A virus subtype H5N1
02
Mechanism of action
Neuraminidase inhibition
03
Biological functions
Viral egressViral spreadSialic acid cleavageAssists viral entryMotility
04
Disease associations
InfectionInfluenzaH5N1 infection
05
Safety considerations
Drug resistance (e.g., H274Y mutation)Antigenic drift leading to reduced vaccine efficacy
06
Interacting drugs
Oseltamivir
2 more in the full profile.
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