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Target intelligence / Profile preview
Neuraminidase Protein of Influenza A H1N1 Virus (NA)
- Target
- NA
- Molecular classification
- Enzyme, Glycoprotein
01
Overview
Neuraminidase (NA) is a surface glycoprotein found on the influenza A virus H1N1 subtype. It enables newly formed virions to be released from infected host cells and prevents their aggregation. NA is a key target for antiviral drugs like oseltamivir and zanamivir, which inhibit its enzymatic activity. Resistance mutations, such as H275Y, can reduce drug efficacy.
- Other names
- Influenza A H1N1 NeuraminidaseH1N1 NA
02
Mechanism of action
Inhibition of neuraminidase enzymatic activity
03
Biological functions
Sialic acid cleavageViral releasePrevention of viral aggregationViral spreadInfection initiation
04
Disease associations
InfectionInfluenza
05
Safety considerations
Drug resistanceMutations affecting drug efficacyCompensatory mutations
06
Interacting drugs
Oseltamivir
1 more in the full profile.
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