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Target intelligence / Profile preview
Neuraminidase Protein of Influenza A H3N2 Virus (NA)
- Target
- NA
- Molecular classification
- Enzyme, Glycoprotein, Viral protein, Neuraminidase
01
Overview
Neuraminidase (NA) is a surface glycoprotein of the influenza A H3N2 virus that plays a crucial role in viral release and spread by cleaving sialic acid residues from host cells. It is a homotetramer with a globular head containing a conserved catalytic site. NA is a major target for antiviral drugs like oseltamivir and zanamivir.
- Other names
- H3N2 NeuraminidaseN2 Neuraminidase (H3N2)Sialidase
02
Mechanism of action
Neuraminidase inhibitors block the enzyme's active site, preventing the release of new virions from infected cells.
03
Biological functions
Virion releaseSialic acid hydrolysisVirus spreadFacilitates penetration through respiratory mucus
04
Disease associations
InfectionInfluenza
05
Safety considerations
Drug resistance mutationsPotential for altered hemagglutination properties
06
Interacting drugs
Oseltamivir (Tamiflu®)
1 more in the full profile.
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