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Target intelligence / Profile preview
Neuregulin‑1 (NRG1)
- Target
- NRG1
- Molecular classification
- Epidermal Growth Factor Family, Growth Factor, Receptor Ligand
01
Overview
Neuregulin‑1 (NRG1) is a trophic factor that plays essential roles in the development and function of multiple organ systems, most notably the nervous system and heart. NRG1 is part of the epidermal growth factor (EGF) family and acts primarily by binding to members of the ERBB family of receptor tyrosine kinases. It produces at least six major types (I–VI) and over 30 isoforms through alternative splicing, resulting in significant structural diversity. Its interaction with ErbB receptors underlies much of its biological activity across systems ranging from neurodevelopment to cardiac physiology.
- Other names
- NDFHeregulins (HRGs)ARIAGGFsSMDF
02
Mechanism of action
NRG1 signals through ERBB receptors (ERBB2, ERBB3, ERBB4) to activate downstream signaling pathways.
03
Biological functions
Neural developmentAxon guidanceSynaptic plasticityOligodendrocyte proliferation and differentiationEnteric nervous system maintenanceCardiac developmentEpithelial cell growth and differentiationCell proliferationCell differentiationCell survivalCell migration
04
Disease associations
SchizophreniaLung cancer
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