Target intelligence / Profile preview

Neurensin-1 (NRSN1)

Target
NRSN1
Molecular classification
Other (vesicular/membrane-associated protein)
01

Overview

Neurensin-1 (NRSN1) is a small, membrane-associated protein encoded by the NRSN1 gene on human chromosome 6[1][3][6]. It is predominantly expressed in neural tissues, where it localizes to transport vesicles, growth cones, neuron projections, and neuronal cell bodies[2][3][6]. Neurensin-1 is predicted to play a key role in nervous system development, neural organelle transport, nerve signal transduction, neurite extension, and memory consolidation[1][6]. Mutations or dysregulation of NRSN1 are associated with several neurodevelopmental disorders, including dyslexia and conditions marked by eye movement abnormalities and ataxia[1]. Currently, there are no known drugs that directly target Neurensin-1, and it is not classified as a conventional therapeutic target such as a receptor or enzyme[1][6].

Other names
Vesicular membrane protein p24VMPNeuro-p24Vesicular membrane protein of 24 kDaneurensin-1neuro-p24vesicular membrane protein p24vesicular membrain protein p24NRSN1
02

Biological functions

Nervous system developmentNeural organelle transportNerve signal transductionNerve growthNeurite extensionMemory consolidation
03

Disease associations

Neurodevelopmental disorders (including dyslexia and neurodevelopmental disorder with eye movement abnormalities and ataxia)

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