Neurexin-3 (NRXN3)

Neurexin-3 (NRXN3) is a member of the neurexin family of presynaptic cell adhesion molecules crucial for synapse formation, differentiation, maturation, and maintenance in the vertebrate nervous system[1][2][5]. Encoded by the NRXN3 gene, it generates multiple isoforms, primarily alpha- (α) and beta- (β) neurexin-3, through alternative promoter usage and extensive alternative splicing[2][5]. Neurexin-3 functions by forming trans-synaptic complexes with various postsynaptic partners, notably neuroligins and leucine-rich-repeat transmembrane neuronal proteins, governing excitatory and inhibitory synapse function, organization, and plasticity[1][3]. Alpha- and beta-neurexin-3 are embedded in the presynaptic membrane and participate directly in neurotransmitter release machinery and trans-synaptic alignment of molecular complexes[1][3][4]. NRXN3 is expressed predominantly in the brain but is also detected in other tissues. Genetic variants of NRXN3 have been associated with susceptibility to neurodevelopmental, neuropsychiatric, and neurodegenerative disorders, as well as addiction and obesity, underscoring its importance in brain health and disease[1][5]. No drugs currently target neurexin-3 directly in clinical practice.

Other names

Neurexin-3NRXN3Neurexin-3-alphaNeurexin-3-betaNeurexin IIIKIAA0743C14orf60Neurexin-3-beta soluble formNeurexin-3-beta C-terminal fragmentNRXN3-CTF