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Target intelligence / Profile preview
Neurexophilin-3 (NXPH3)
- Target
- NXPH3
- Molecular classification
- Other (secreted protein/neuropeptide-like molecule)
01
Overview
Neurexophilin-3 is a secreted protein encoded by the NXPH3 gene. It is thought to act as a ligand for alpha-neurexins, resembling neuropeptides, and is involved in signaling receptor binding and neuropeptide signaling pathways. Predominantly located in the extracellular region, it might play a role in synaptic organization and signaling in the nervous system. Genetic alterations in NXPH3 have been associated with neurological diseases, including autism spectrum disorder and lissencephaly. However, Neurexophilin-3 is not currently classified as a conventional drug target, such as a receptor, enzyme, or transporter.
- Other names
- NXPH3Neurexophilin-3KIAA1159NPH3UNQ687/PRO1327
02
Biological functions
Signaling receptor bindingNeuropeptide signaling pathway
03
Disease associations
Autism Spectrum DisorderLissencephaly 9 with complex brainstem malformation
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