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Target intelligence / Profile preview
Neurexophilin and PC-esterase domain family member 4 (NXPE4)
- Target
- NXPE4
- Molecular classification
- Protein coding gene, Family member of neurexophilins and PC-esterase domain proteins, Other (does not fit classic receptor, enzyme, transporter, channel, etc.)
01
Overview
Neurexophilin and PC-esterase domain family member 4 (NXPE4) is a protein-coding gene expressed in humans and other species. It belongs to the neurexophilin and PC-esterase domain protein family, with related genes including NXPE1-3. NXPE4 has been proposed as a prognostic biomarker for colorectal cancer: lower mRNA expression in tumor tissues is correlated with certain tumor characteristics and worse outcomes in colorectal cancer patients. There is no experimental evidence for its molecular function or biological process, nor is there evidence that it is targeted by drugs or considered a therapeutic target. NXPE4 is sometimes detected in extracellular exosomes. Common aliases include C11orf33 and FAM55D. At present, NXPE4 serves more as a biomarker than as a classical druggable target.
- Other names
- C11orf33FAM55DNXPE4
02
Mechanism of action
None reported. Mechanisms of action for drugs are not established, as no drugs target this molecule
03
Biological functions
No experimental evidence on molecular function or biological process as of August 2025 in mouse and human entriesPotential role in intercellular signaling (as a family member)May be present in extracellular exosomes
04
Disease associations
Prognostic biomarker for colorectal cancer: Lower expression is associated with tumor characteristics and survival outcomes in colorectal cancerNo established pathogenic mechanism or disease association beyond biomarker status
05
Safety considerations
None reported. No therapeutic targeting, and thus no safety profile or challenges described
06
Interacting drugs
None reported. There are no drugs known to interact directly with NXPE4
07
Biomarkers
Potential prognostic biomarker for overall survival and relapse-free survival in colorectal cancer
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