Neurite extension and migration factor (NEXMIF)

NEXMIF (Neurite extension and migration factor, also known as KIAA2022) is a gene located on the X chromosome whose protein product is highly expressed in the developing and adult brain, especially in the cerebral cortex and cerebellum. The protein mediates neurite outgrowth by regulating cell-cell and cell-matrix adhesion—primarily via N-cadherin and β1-integrin pathways—thereby playing a crucial role in neuronal migration and differentiation. It is also implicated in maintaining genomic stability, responding to oxidative and cellular stress, and regulating the expression of genes involved in cellular adhesion and stress responses. Loss-of-function mutations in NEXMIF cause X-linked intellectual disability (XLMR 98), are associated with autism spectrum disorder, epilepsy, and, potentially, diabetes, and can lead to reduced beta-cell proliferation in the pancreas. The gene is not a classical drug target such as a receptor, enzyme, or transporter, but a cytoplasmic protein with regulatory functions in neurodevelopment and possibly metabolic regulation.

Other names

KIAA2022XPNMRX98KIDLIAXLID98XLMR protein related to neurite extensionXLMR-related protein