Neuroactive ligand-receptor interaction pathway

The neuroactive ligand-receptor interaction pathway refers to the collection of cell signaling events where various neuroactive ligands (such as neurotransmitters, hormones, and neuropeptides) bind to and activate their respective cell membrane receptors, ultimately regulating intracellular signaling and neural function. This pathway encompasses over 300 genes encoding receptors and ligands crucial for neural information processing, cognition, and brain health[2][3]. It features key receptor classes including G protein-coupled receptors, ligand-gated ion channels, and nuclear hormone receptors[3]. Dysregulation in this pathway is associated with neurological and psychiatric disorders (such as Alzheimer’s disease and schizophrenia), cancer, and cardiovascular conditions[4][5][6].

Other names

Neuroactive ligand-receptor signalingNeuroactive ligand signaling pathway