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Target intelligence / Profile preview
Neuroactive Microbial Metabolites
- Molecular classification
- Neurotransmitter, Small molecule, Metabolite, Short-chain fatty acid, Indole compound, Catecholamine
01
Overview
Neuroactive microbial metabolites are small molecules produced or modified by gut microbiota that can influence the nervous system, including the brain, via direct or indirect mechanisms. These include neurotransmitters (such as GABA, serotonin, dopamine), their precursors (like tryptophan derivatives), short-chain fatty acids (SCFAs), bile acid derivatives, and other bioactive compounds. They play a key role in the gut-brain axis, impacting neuronal excitability, behavior, cognition, mood, neurodevelopment, and immune responses. Alterations in their abundance/composition have been associated with neurological disorders.
- Other names
- Gut microbiota-derived neuroactive compoundsMicrobiome-derived neuroactive moleculesNeurotransmitters produced by gut bacteriaSCFAsShort-chain fatty acidsGABASerotoninDopamineTryptophan derivativesBile acid derivatives
02
Mechanism of action
Modulation of neurotransmitter levels and activity; regulation of inflammation and immune response; promotion of neurogenesis and neural differentiation.
03
Biological functions
NeurotransmissionNeuromodulationRegulation of neuronal excitabilityModulation of synaptic transmissionRegulation of immune responseModulation of inflammationNeurogenesisEnteric nervous system stimulationRegulation of GI motilityMood regulationCognitive function
04
Disease associations
Autism Spectrum Disorder (ASD)DepressionAnxiety disordersEpilepsyNeurological disordersNeurodevelopmental disorders
05
Safety considerations
Potential for dysbiosisVariability in individual responses to probiotics/prebioticsNeed for personalized approaches based on microbiome profilingLong-term effects of microbiome modulation are not fully understood
06
Interacting drugs
Probiotics
2 more in the full profile.
07
Biomarkers
Levels of GABA in serum/fecesLevels of serotonin in serum/fecesLevels of dopamine in serum/fecesLevels of SCFAs (acetate, propionate, butyrate) in serum/fecesGut microbiome composition (dysbiosis)
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