Neuroblastoma breakpoint family member 1 (NBPF1)

Neuroblastoma breakpoint family member 1 (NBPF1) is a protein encoded by the NBPF1 gene in humans, a unique member of the NBPF gene family most notable for its disruption in neuroblastoma patients and for harboring multiple DUF1220 domain repeats[1][3][4]. NBPF1 appears to act as a tumor suppressor, as studies show that its expression can inhibit anchorage-independent cell growth, induce G1 cell cycle arrest, and upregulate cell cycle inhibitor p21 via p53-dependent and independent mechanisms; effects can be cell type–specific[3]. Its precise molecular function is not fully elucidated, but it is predicted to be a nuclear protein with DNA binding motifs related to transcription factors, suggesting a potential role in transcriptional regulation[1][5]. NBPF1 is rich in structural domains (such as coiled-coil and DUF1220) thought to contribute to neurodevelopment, and its copy number variation has been implicated in brain evolution and possibly neurodevelopmental disease[1]. NBPF1 disruption is frequently observed in cancer-associated chromosomal rearrangements, and low NBPF1 levels associate with aggressive disease and poorer outcomes, particularly in neuroblastoma[3][5]. No drugs directly targeting NBPF1 are approved or in clinical development, nor are clear safety concerns documented, as therapeutic targeting is currently investigational.

Other names

NBPF1NBPF member 1KIAA1693FLJ20719neuroblastoma breakpoint family member 1AB13AB14AB23AD2NBGNBPF

Not applicable (no approved drugs directly target NBPF1)