Neuroblastoma breakpoint family member 10 (NBPF10)

Neuroblastoma breakpoint family member 10 (NBPF10) is a protein encoded by the NBPF10 gene in humans and is part of the neuroblastoma breakpoint family (NBPF), comprising many recently expanded, primate-specific genes primarily located in segmental duplications on chromosome 1q21.1[1][2][3][6]. NBPF10 contains repeated DUF1220 (also known as Olduvai) protein domains, a hallmark of this gene family, which are thought to play roles in brain evolution and have been linked to the severity of neurodevelopmental conditions[2][3][4]. NBPF10 has very low threonine content and may be less susceptible to post-translational modifications[1]. Although its function is not well characterized, altered expression or copy number variations of NBPF family genes are associated with a spectrum of developmental and neuropsychiatric diseases, congenital anomalies, and cancer, but there is no evidence NBPF10 acts as a receptor, enzyme, transporter, or as a direct drug target[1][2][3]. NBPF10 may have biomarker potential in odontoblasts, but no defined role as a therapeutic target has been documented[1]. There are no currently known interacting drugs, mechanisms of action, or safety concerns related to NBPF10 specifically.

Other names

AB6AG1NBPF9NBPF family member NBPF10neuroblastoma breakpoint family member 10NBPFA_HUMAN

Not applicable (no known therapeutic targeting)