Neuroblastoma breakpoint family member 11 (NBPF11)

Neuroblastoma breakpoint family member 11 (NBPF11) is a protein encoded by the NBPF11 gene in humans, belonging to the neuroblastoma breakpoint (NBPF) family. The NBPF family comprises multiple, highly related genes mostly located on chromosome 1, characterized by repetitive exon structures and a high degree of sequence homology. NBPF11 is predicted to reside in the cytoplasm, contains two coiled-coil regions and six Olduvai domains (conserved regions of uncertain function). Its function remains unknown, and its association with disease is based largely on genomic position and family-level implications (e.g., involvement of NBPF genes in neuroblastoma and chromosomal syndromes). There is currently no established role for NBPF11 as a drug target or clinical biomarker, nor are there known drugs or safety concerns specifically connected to this protein.

Other names

NBPF24Neuroblastoma breakpoint family member 24NBPFB_HUMAN (UniProt entry)NBPF member 11neuroblastoma breakpoint family, member 11Chromosome 1Q21.1 Deletion Syndrome gene (contextual disease association)

None known (no drugs targeting NBPF11 are identified)