Neuroblastoma breakpoint family member 4 (NBPF4)

Neuroblastoma breakpoint family member 4 (NBPF4) is one of dozens of recently duplicated genes that make up the primate-expanded NBPF gene family, most of which are located on human chromosome 1 and are characterized by multiple tandem DUF1220 protein domains of unclear function[1][3][4]. Copy number variations in this gene cluster (not specifically NBPF4) have been linked to a wide range of neurodevelopmental and congenital diseases[3][4]. NBPF4 itself is not a receptor, enzyme, transporter, or classical druggable target, but has been shown in colorectal cancer models to act as a tumor suppressor: its expression is decreased in tumor-derived tissues and cell lines, and increasing NBPF4 inhibits tumorigenesis, cell proliferation, migration, invasion, and EMT both in vitro and in vivo[2][3]. Mechanistically, NBPF4 regulates cancer-associated gene networks (e.g., the ETFA/miR-17-3p/ZFP36/EZH2 axis) but is not known to be engaged by any approved drugs, nor considered pharmacologically tractable at this time[2][3].

Other names

NBPF4FLJ32833Neuroblastoma breakpoint family member 4NBPF family member NBPF4

Not applicable; there are currently no approved drugs or therapies known to specifically target NBPF4.