Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Neuroblastoma breakpoint family member 8 (NBPF8)
- Target
- NBPF8
- Molecular classification
- Other (NBPF family protein; DUF1220 domain-containing)
01
Overview
Neuroblastoma breakpoint family member 8 (NBPF8) is a member of the NBPF gene family located on chromosome 1q21.1[1][2][4]. NBPF genes are characterized by the presence of multiple DUF1220 protein domains, which have undergone significant expansion in humans and are present as segmental duplications. While the specific function of NBPF8 is unknown, copy number variations and altered expression in the NBPF family have been associated with various developmental and neuropsychiatric disorders (including microcephaly, macrocephaly, autism, schizophrenia, and cognitive disabilities) as well as certain cancers such as neuroblastoma. NBPF8 itself is not considered a drug target, and there is no established pharmacological interaction or mechanism of action. The family is notable for containing some pseudogenes, and its evolutionary characteristics may have contributed to human brain development[1][2][5][6][8].
- Other names
- NBPF8NBPF8PNBPF family member NBPF8Neuroblastoma breakpoint family member 8Putative neuroblastoma breakpoint family member 8
02
Biological functions
Other (unknown; possibly neurodevelopmental)
03
Disease associations
CancerNeurodevelopmental disordersCongenital heart diseaseCongenital kidney and urinary tract anomalies
Beyond the preview
Go deeper on Neuroblastoma breakpoint family member 8 (NBPF8).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Neuroblastoma breakpoint family member 8 (NBPF8).