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Target intelligence / Profile preview
Neuroblastoma RAS viral oncogene homolog (NRAS)
- Target
- NRAS
- Molecular classification
- Small GTPase, Proto-oncogene
01
Overview
The Neuroblastoma RAS viral oncogene homolog (NRAS) encodes a small G-protein central for cellular growth regulation via major signaling cascades. Its aberrant activation through mutation drives multiple human cancers—including those resistant or refractory—to standard therapies.
- Other names
- ALPS4CMNSN-rasNCMSNRAS1NS6NRAS proto-oncogeneGTPase
02
Mechanism of action
GTPase activity, regulates downstream signaling pathways (MAPK/ERK, PI3K)
03
Biological functions
Signal transductionCell proliferationCell differentiationRegulation of cell division
04
Disease associations
CancerMelanomaHepatocellular carcinomaNeuroblastomaLeukemiaGiant congenital melanocytic nevus syndrome
05
Safety considerations
Constitutive activation of MAPK/ERK and PI3K pathwaysTherapy resistance (e.g., sorafenib)Compensatory upregulation of other Ras isoforms (e.g., KRAS) upon NRAS inhibition
06
Interacting drugs
Sorafenib (resistance contributor)
1 more in the full profile.
07
Biomarkers
NRAS mutation status (prognostic)NRAS isoform expression (prognostic/therapeutic response prediction)
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