Neurofibromin 1 pseudogene 1 (NF1P1)

Neurofibromin 1 pseudogene 1 (NF1P1) is a processed pseudogene in the human genome with sequence similarity to the functional neurofibromin 1 gene (NF1), which encodes the tumor suppressor protein neurofibromin. Pseudogenes like NF1P1 lack the ability to encode functional protein products and do not participate in biological pathways or act as drug targets. NF1P1 should not be confused with the functional NF1 gene, which is linked to neurofibromatosis type 1 and tumor suppression. NF1P1 is listed in the NCBI Gene database as a pseudogene, not a protein-coding gene or known therapeutic target. The correct therapeutic target is the functional neurofibromin 1 gene (NF1), not its pseudogenes, as NF1 pseudogenes are non-functional DNA sequences that may arise from gene duplication and transposition events. Therefore, NF1P1 is not a functional gene or protein and cannot act as a receptor, enzyme, or any classical drug target. Additionally, aliases like "Albright osteodystrophy" are incorrect and refer to a different condition (a hormonal disorder associated with the GNAS gene), which is unrelated to the NF1P1 pseudogene. For molecular and drug discovery purposes, NF1P1 should not be considered a target of interest.

Other names

NF1HHSNF1P1