Neurofibromin 1 pseudogene 11 (NF1P11)

Neurofibromin 1 pseudogene 11 (NF1P11) is a non-coding pseudogene related to the neurofibromin 1 (NF1) gene, which encodes a tumor suppressor involved in Ras signaling and whose mutations cause neurofibromatosis type 1. Pseudogenes like NF1P11 are segments of genomic DNA that resemble functional genes but typically do not produce functional proteins due to mutations, truncations, or loss of regulatory elements. NF1P11 does not encode an active neurofibromin protein and is not associated with any known cellular function, disease role, or drug interaction. The term "NF1P11" is a systematic genomic annotation, and this locus is not considered a therapeutic target or a component of disease mechanisms[3][4]. The functional NF1 gene is on chromosome 17q11.2 and is a major tumor suppressor[1][2][5]. Multiple NF1 pseudogenes exist in the genome, found on other chromosomes (e.g., chromosomes 2, 14, 22, etc.), and share sequence identity to parts of NF1 but lack coding or regulatory capacity[3]. There is no evidence or literature supporting a functional or pathogenic role for NF1P11 specifically.

Other names

NF1 pseudogene 11