Neurofibromin 1 pseudogene 6 (NF1P6)

Neurofibromin 1 pseudogene 6 (NF1P6) is a processed pseudogene related to the NF1 gene, which encodes neurofibromin—a tumor suppressor protein[1][4][6][7]. Pseudogenes like NF1P6 arise from duplication and transposition events—NF1 pseudogenes on chromosomes 14 and 22 originated from larger duplications of the NF1 gene[3]. Pseudogenes are generally considered to be nonfunctional, lacking protein-coding capacity. However, some can exert regulatory effects via noncoding RNA transcripts, influencing gene expression or serving as microRNA decoys[5]. For NF1P6 specifically, there is no published evidence of protein expression, disease role, or direct interaction with drugs. Explanation of "is_incorrect": The query refers to NF1P6 as a "target molecule/receptor"; however, pseudogenes like NF1P6 do not typically encode functional proteins and are not considered therapeutic targets such as receptors, enzymes, or transporters[5]. Its naming and classification reflect its status as a pseudogene, not a functional target. There is no evidence in the literature that NF1P6 is misspelled, but there is insufficient evidence that this pseudogene meets the criteria for a druggable or disease-relevant biomolecule. Additional relevant context: - Neurofibromin (from the NF1 gene) is a GTPase-activating protein crucial for regulating Ras-MAPK signaling and acts as a tumor suppressor; mutations cause neurofibromatosis type 1 and other syndromes[1][4][6][7]. - Pseudogenes like NF1P6 are often retained in the genome but considered non-functional unless shown to affect regulation of parental genes or other pathways[3][5].

Other names

Em:AP000532.C22.1neurofibromin pseudogene 6