Neurogenesis and angiogenesis regulatory pathways

Neurogenesis and angiogenesis regulatory pathways represent the complex, coordinated signaling networks that govern the simultaneous development and repair of the nervous and vascular systems (Louissaint et al., 2002, Neuron). These pathways are linked through shared molecular mediators such as vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF), and the Notch and Wnt signaling systems, which facilitate "neurovascular coupling" (Ruiz de Almodovar et al., 2009, Nature Reviews Neuroscience). In the central nervous system, these processes are critical for maintaining the neurogenic niche, where endothelial cells provide essential signals for neural stem cell self-renewal and differentiation (Sun et al., 2003, Journal of Clinical Investigation). Dysregulation of these pathways is implicated in various pathologies, including neurodegenerative diseases like Alzheimer's, ischemic stroke, and certain types of cancer where aberrant angiogenesis supports tumor growth (Zacchigna et al., 2008, Journal of Internal Medicine). While these pathways offer numerous therapeutic opportunities, targeting them is challenging due to the risk of systemic side effects and the need for precise spatial and temporal control of signaling (Carmeliet, 2003, Nature Medicine).

Other names

Neurovascular couplingAngioneurogenesisNeurovascular niche regulation

Modulation of growth factor signaling (e.g., VEGF, BDNF) and developmental pathways (e.g., Notch, Wnt) to regulate the formation and maintenance of blood vessels and neurons.