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Neurogenesis Modulator
- Molecular classification
- Neurotransmitter receptor, Growth factor, Cytokine, Transcription factor, Epigenetic regulator, MicroRNA
01
Overview
A "neurogenesis modulator" is a functional category encompassing various molecules, receptors, signaling pathways, and epigenetic mechanisms that regulate the process of neurogenesis—the generation of new neurons from neural stem/progenitor cells in the brain. These modulators can either promote or inhibit different stages of neurogenesis, including proliferation, differentiation, migration, maturation, and integration of new neurons. Examples include glutamate receptors, growth factors like Wnt and BMP, transcriptional regulators like REST/NRSF, and microRNAs.
- Other names
- Neurogenesis regulatorNeurogenesis influencing factor
02
Mechanism of action
Various mechanisms affecting different stages of neurogenesis (proliferation, differentiation, migration, maturation, integration) through extracellular signals, receptors, transcriptional regulation, and epigenetic control.
03
Biological functions
Cell proliferationCell differentiationCell migrationSynaptic plasticityCognitive functionAdaptive response to stress/injuryNeural stem cell maintenance
04
Disease associations
Cognitive impairmentNeurodegenerative diseaseBrain injuryNeurological disorders
05
Safety considerations
Potential for uncontrolled cell proliferation (tumorigenesis)Off-target effects on other brain regionsDisruption of existing neural circuits
06
Interacting drugs
NMDA receptor antagonists
3 more in the full profile.
07
Biomarkers
Levels of neurogenesis-related proteins in CSFHippocampal volumeExpression levels of neurogenesis-related genes
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