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Neurogenesis Stimulants
- Molecular classification
- Small molecules, Psychoactive substances, Enzyme inhibitors (BAX inhibitors)
01
Overview
Neurogenesis stimulants are agents that promote or enhance the formation of new neurons in the brain, primarily in the hippocampus. These stimulants are being explored as potential therapeutic strategies for cognitive enhancement and mood disorder treatment. Examples include DMT, psilocybin (at low doses), and experimental BAX inhibitors. Unlike general CNS stimulants, which primarily affect neurotransmitter levels, neurogenesis stimulants directly influence neuron production and survival.
- Other names
- Agents that promote neurogenesisNeurogenic agentsNeurogenesis enhancers
02
Mechanism of action
Various, including anti-apoptotic effects (e.g., BAX inhibition), serotonergic modulation, and neural stem cell proliferation.
03
Biological functions
NeurogenesisCell proliferationCell survivalSynaptic plasticityHippocampal function
04
Disease associations
DepressionCognitive declineNeurodegenerative diseasesMood disorders
05
Safety considerations
Potential for off-target effectsLong-term effects on brain function are not fully understoodRisk of psychiatric side effectsDosage sensitivity (e.g., psilocybin)Potential for drug interactions
06
Interacting drugs
DMT (Ayahuasca)
2 more in the full profile.
07
Biomarkers
Hippocampal volumeLevels of neurogenesis markers (e.g., doublecortin)Cognitive performance tests
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