Neurogenic Inflammation Pathway

Neurogenic inflammation is a physiological process in which sensory nerve fibers, particularly nociceptors, release neuropeptides and other mediators that initiate and propagate an inflammatory response. This pathway plays a key role in pain conditions, tissue injury responses, and various chronic inflammatory diseases. Key components include sensory neurons, endothelial cells, immune cells, and neuropeptides such as Substance P and CGRP. Targeting elements within this pathway has been explored for treating migraines, neuropathic pain states, asthma exacerbations, psoriasis flares, among others.

Modulation of neuropeptide release or receptor activity to reduce inflammatory response and pain signaling.