Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Neurogenic locus notch homolog protein 1 (NOTCH1)
- Target
- NOTCH1
- Molecular classification
- Receptor, Single-pass transmembrane receptor
01
Overview
Neurogenic locus notch homolog protein 1 (NOTCH1) is a single-pass transmembrane receptor that plays critical roles in cell fate determination during development and tissue homeostasis. Upon ligand binding, proteolytic cleavage releases the Notch intracellular domain (NICD), which translocates to the nucleus and regulates target gene expression. Aberrant NOTCH1 signaling is implicated in cancer and other developmental disorders.
- Other names
- Notch 1hN1Translocation-associated notch protein TAN-1Translocation-associated notch protein TAN‑‑‑‑‑-----–TAN‑–TAN‑–TAN‑–TAN
02
Mechanism of action
Inhibition of NOTCH1 signaling
03
Biological functions
Cell fate determinationDifferentiationSignal transductionAngiogenesisNeurogenesisLeft/right symmetry establishmentResponse to injury
04
Disease associations
Congenital heart defectsCancerDevelopmental disorders
05
Safety considerations
Context-dependent effects on tumorigenesis
Beyond the preview
Go deeper on Neurogenic locus notch homolog protein 1 (NOTCH1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Neurogenic locus notch homolog protein 1 (NOTCH1).